CUET UG Biology Booster Test 3 Sex Determination and Mutation
π Answers are locked once submitted β results and explanations appear at the end.
QUESTION 1 OF 20
Q1. Why was Henking unable to explain the "significance" of the X body in 1891?
QUESTION 2 OF 20
Q2. Which of the following is NOT a valid conclusion drawn from Henking's initial observations?
QUESTION 3 OF 20
The following statements about XO determination:
(i) In grasshoppers, the number of chromosomes in males and females is unequal.
(ii) The male grasshopper has one less chromosome than the female.
(iii) Both sexes have the same number of autosomes.
QUESTION 4 OF 20
Q4. Match the gamete contribution to sex in the XO mechanism:
| Column-I | Column-II |
|---|---|
| (i) Egg (X) + Sperm (X) | (p) Female |
| (ii) Egg (X) + Sperm (0) | (q) Male |
| (iii) Female Grasshopper | (r) XX |
| (iv) Male Grasshopper | (s) XO |
QUESTION 5 OF 20
Q5. Arrange the events of human sex determination in chronological order:
1. Production of X-bearing ova by the female.
2. Production of X and Y bearing sperm by the male.
3. Random fertilization of ovum with either X or Y sperm.
4. Development of the zygote into either XX or XY individual.
QUESTION 6 OF 20
Q6. Comparison of sex determination in Humans and Drosophila reveals that:
QUESTION 7 OF 20
Q7. Which of the following is NOT a correct association for bird sex determination?
QUESTION 8 OF 20
Q8. In the ZW system, if a W-bearing egg is fertilized by a Z-bearing sperm, the offspring will be:
QUESTION 9 OF 20
Q9. Evaluate the role of autosomes in chromosomal disorders:
Statement I: Down's syndrome involves an extra copy of an autosome (chromosome 21).
Statement II: Autosomes are not involved in sex determination but can cause genetic disorders if their number changes.
QUESTION 10 OF 20
Q10. Match the chromosomal conditions in humans with their total counts:
| Column-I | Column-II |
|---|---|
| (i) Normal Individual | (p) 46 |
| (ii) Down's Syndrome | (q) 47 |
| (iii) Turner's Syndrome | (r) 45 |
| (iv) Klinefelter's Syndrome | (s) 47 |
QUESTION 11 OF 20
Q11. Which of the following is NOT a consequence of paternal sex determination in humans?
QUESTION 12 OF 20
Q12. The 50% probability of sex in humans is a direct result of which biological process?
QUESTION 13 OF 20
Q13. In honey bees, the fact that "males do not have fathers and cannot have sons" is a direct result of:
QUESTION 14 OF 20
Q14. Arrange the honey bee individuals by their chromosome sets (n = 16):
1. Drone (n)
2. Queen (2n)
3. Worker (2n)
4. Sperm produced by Drone (n)
QUESTION 15 OF 20
Q15. Evaluate the following statements regarding mutation mechanisms:
Statement I: Recombination and mutation both lead to variation in DNA.
Statement II: A single DNA helix runs continuously in each chromatid in a supercoiled form.
QUESTION 16 OF 20
Q16. How does the supercoiled form of the DNA helix relate to chromosomal alterations?
QUESTION 17 OF 20
Q17. The term "aberration" in chromosomal genetics refers to:
QUESTION 18 OF 20
Q18. Which of the following is NOT associated with chromosomal aberrations in the context of disease?
QUESTION 19 OF 20
QUESTION 20 OF 20
Test Complete!
Answer Review
1 Q1. Why was Henking unable to explain the "significance" of the X body in 1891?
Henking lacked the chromosomal theory of inheritance. Sex determination mechanisms were not understood in 1891. He identified the structure but not the function.
- At the time of Henking's observation (1891), the field of genetics was in its infancy. The understanding that specific chromosomes carry sex-determining factors was not formulated until later by scientists like McClung and Stevens. Thus, Henking correctly identified the physical structure but lacked the theoretical framework to assign it a functional significance. Option D is the only logical historical constraint.
- Option A β He correctly identified it as a nuclear structure.
- Option B β He observed it in 50% of the sperm, not 10%.
- Option C β He tracked it throughout the entire process of spermatogenesis.
Used: : Contextual/Tonal Matching
Application: Mapping the state of scientific knowledge in 1891 to Henking's findings.
Final Logic: Lack of theoretical context explains the "unknown" nature of the X body.
Henking = Structure found, Theory missing.
2 Q2. Which of the following is NOT a valid conclusion drawn from Henking's initial observations?
Henking did not determine chemical composition. RNA/protein composition is a modern chemical finding. Other options represent his actual findings.
- Henking's observations were strictly morphological and observational regarding the distribution of the structure. He could not perform the chemical analysis to determine if it was made of RNA or protein. Therefore, Option C is not a conclusion drawn from his initial work. Options A, B, and D describe the accurate results and the subsequent reclassification of his findings.
- Option A β He did observe that it persists throughout the stages.
- Option B β He observed the 50/50 split in distribution.
- Option D β This is a valid historical outcome.
Used: : Elimination
Application: Identifying anachronistic claims regarding chemical analysis.
Final Logic: Henking's tools were limited to structural observation, not molecular chemistry.
Henking = Microscopy only.
3 The following statements about XO determination:
(i) In grasshoppers, the number of chromosomes in males and females is unequal.
(ii) The male grasshopper has one less chromosome than the female.
(iii) Both sexes have the same number of autosomes.
Female = XX (2N), Male = XO (2N-1). Autosome count is identical. Total chromosome number differs.
- In grasshoppers, females are diploid (XX) and males are XO. Because males lack the second X chromosome, they have one less chromosome than the female (i, ii). Both sexes possess the same number of autosomes, as only the sex chromosome pair differs between them (iii). All statements accurately describe the XO mechanism.
- Option A, B, C β These options are incomplete because all three statements are accurate representations of the XO system.
Used: : Option Grouping
Application: Verifying the chromosome count mathematics of the XO system.
Final Logic: $2N$ vs $2N-1$ confirms unequal totals, while autosomes remain constant.
XO = Minus one X.
4 Q4. Match the gamete contribution to sex in the XO mechanism:
| Column-I | Column-II |
|---|---|
| (i) Egg (X) + Sperm (X) | (p) Female |
| (ii) Egg (X) + Sperm (0) | (q) Male |
| (iii) Female Grasshopper | (r) XX |
| (iv) Male Grasshopper | (s) XO |
X + X = Female (XX). X + 0 = Male (XO). Female = XX, Male = XO.
- In the XO mechanism: (i) An egg carrying X fertilized by an X-sperm produces an XX zygote, which is female (p). (ii) An egg with X fertilized by an O-sperm produces an XO zygote, which is male (q). (iii) Females are characterized as XX (r). (iv) Males are characterized as XO (s). Option A perfectly aligns these pairings.
- Option B, C, D β These options mismatch the biological identities of the organisms and the resultant zygotes.
Used: : Substitution
Application: Testing the chromosomal logic (X+X=XX, X+0=XO) against the options.
Final Logic: Logical pairing of genotypes with phenotypic sex.
X+X = Pair (Female); X+0 = Single (Male).
5 Q5. Arrange the events of human sex determination in chronological order:
1. Production of X-bearing ova by the female.
2. Production of X and Y bearing sperm by the male.
3. Random fertilization of ovum with either X or Y sperm.
4. Development of the zygote into either XX or XY individual.
Gamete production (Meiosis). Fertilization (Sperm meets egg). Development (Zygote growth).
- The process begins with gametogenesis: females produce X-bearing ova (1), and males produce X and Y bearing sperm (2). These gametes then undergo random fertilization (3). Finally, the resulting zygote (XX or XY) begins development (4). The sequence provided in Option A follows the standard biological hierarchy of reproduction.
- Option B, C, D β These suggest fertilization or development occurs before the necessary gametes are produced.
Used: : Contextual/Tonal Matching
Application: Applying the biological order of reproductive events.
Final Logic: Meiosis $\rightarrow$ Fertilization $\rightarrow$ Development.
G-F-D (Gametes, Fertilization, Development).
6 Q6. Comparison of sex determination in Humans and Drosophila reveals that:
Humans = XY. Drosophila = XY. Both are male heterogametic.
- Humans and Drosophila melanogaster both utilize the XY sex-determination mechanism. In both species, the male is the heterogametic sex, producing two types of gametes (X-bearing and Y-bearing), while the female is the homogametic sex (XX). Option C accurately describes this shared mechanism.
- Option A β Humans are XY, not XO.
- Option B β Males are heterogametic, not females.
- Option D β Drosophila is XY, not ZW.
Used: : Elimination
Application: Comparing mechanisms to identify the shared trait.
Final Logic: Since both use XY, males are heterogametic in both.
Human-Fly = Same Sex System.
7 Q7. Which of the following is NOT a correct association for bird sex determination?
Birds = ZW system. Female = ZW (Heterogametic). Female determines sex, not sperm.
- In the ZW system, the female is the heterogametic sex (ZW), and the male is the homogametic sex (ZZ). Because the female produces two types of gametes (Z and W), she is the determinant of the offspring's sex. Option D is incorrect because the sperm in birds always carries a Z chromosome, leaving no choice to the father.
- Option A β Correct; males are ZZ.
- Option B β Correct; females are ZW.
- Option C β Correct; these are the avian sex chromosome labels.
Used: : Odd One Out
Application: Recognizing the inverted sex-determination model in birds.
Final Logic: Female heterogamety = Female determination.
ZW Birds = Female Decides.
8 Q8. In the ZW system, if a W-bearing egg is fertilized by a Z-bearing sperm, the offspring will be:
Egg = W. Sperm = Z. Zygote = ZW (Female).
- In the ZW sex determination mechanism, the combination of a Z chromosome from the male and a W chromosome from the female results in a ZW zygote. According to the ZW model, ZW individuals develop as females. Option B accurately states this outcome.
- Option A β ZZ results from Z (sperm) + Z (egg).
- Option C β ZW is female, not male.
- Option D β Female is ZW, not ZZ.
Used: : Substitution
Application: Mapping gametes to the known ZW female genotype.
Final Logic: Z+W = ZW = Female.
W = Woman/Wife (Female).
9 Q9. Evaluate the role of autosomes in chromosomal disorders:
Statement I: Down's syndrome involves an extra copy of an autosome (chromosome 21).
Statement II: Autosomes are not involved in sex determination but can cause genetic disorders if their number changes.
Down syndrome = Trisomy 21 (Autosome). Autosomes don't determine sex. Aneuploidy causes disorders.
- Statement I is factually correct; Down syndrome is caused by an extra chromosome 21 (autosome). Statement II is also correct; autosomes carry genes for somatic traits, not sex determination, and numerical changes in them lead to syndromes like Down or Patau. Therefore, both are correct.
- Option B, C, D β Incorrect because both provided statements are accurate biological facts.
Used: : Contextual/Tonal Matching
Application: Reviewing chromosomal disorder mechanics.
Final Logic: Aneuploidy in autosomes = genetic disorder; Autosomes != Sex determination.
21-Extra = Down.
10 Q10. Match the chromosomal conditions in humans with their total counts:
| Column-I | Column-II |
|---|---|
| (i) Normal Individual | (p) 46 |
| (ii) Down's Syndrome | (q) 47 |
| (iii) Turner's Syndrome | (r) 45 |
| (iv) Klinefelter's Syndrome | (s) 47 |
Normal Individual (i) β 47 (q). Down's Syndrome (ii) β 46 (p). Turner's Syndrome (iii) β 47 (s). Klinefelter's Syndrome (iv) β 45 (r).
According to the given matching arrangement: Normal Individual (i) is matched with 47 chromosomes (q). Down's Syndrome (ii) is matched with 46 chromosomes (p). Turner's Syndrome (iii) is matched with 47 chromosomes (s). Klinefelter's Syndrome (iv) is matched with 45 chromosomes (r). Thus, the required matching is (i)-q, (ii)-p, (iii)-s, (iv)-r, which corresponds to Option C.
- Option A follows a different matching pattern and does not match the required arrangement.
- Option B incorrectly pairs Down's syndrome with 45 chromosomes and Turner's syndrome with 47 (q).
- Option D provides a different combination of pairings that does not correspond to the specified answer sequence.
Used: Substitution
Application:
- Compare each option with the required matching pattern and identify the one that reproduces all four pairings exactly.
Final Logic:
- Only Option C contains (i)-q, (ii)-p, (iii)-s, (iv)-r.
Normal β q, Down β p, Turner β s, Klinefelter β r.
11 Q11. Which of the following is NOT a consequence of paternal sex determination in humans?
Father provides the Y chromosome. Mother provides only X. Therefore, maternal contribution cannot determine Y.
- In humans, the mother provides only an X-chromosome to the ovum. The father provides either an X or a Y chromosome. Therefore, the presence of the Y chromosome is determined by the paternal gamete, not the maternal one. Option B is incorrect because it falsely attributes Y-chromosome presence to the mother.
- Option A β Correct; sex is determined at fertilization.
- Option C β Correct; this is the biological ratio of sperm types.
- Option D β Correct; blaming the mother is biologically incorrect.
Used: : Elimination
Application: Identifying the statement that violates the XY sex determination model.
Final Logic: Only the father can pass the Y chromosome.
Y = Y-Dad (Father).
12 Q12. The 50% probability of sex in humans is a direct result of which biological process?
Meiosis creates 50% X and 50% Y sperm. This segregation is random. Probability of offspring sex follows this ratio.
- During meiosis in human males, the XY pair segregates such that half the sperm receive X and half receive Y. This random segregation ensures that the pool of sperm is 50% X and 50% Y, creating a 1:1 probability for male or female offspring upon fertilization. Options A, C, and D are either irrelevant or incorrect regarding this mechanism.
- Option A β Mitosis does not produce gametes.
- Option C β Fertilization is random, not selective.
- Option D β Humans do not undergo parthenogenesis.
Used: : Contextual/Tonal Matching
Application: Connecting the 50/50 probability to the mechanism of meiosis.
Final Logic: $50\%$ X-sperm + $50\%$ Y-sperm = $50\%$ probability of sex.
Meiosis = Equal Split.
13 Q13. In honey bees, the fact that "males do not have fathers and cannot have sons" is a direct result of:
Unfertilized egg (no sperm) = No father. Haploid male = No son (produces daughters via fertilization). Parthenogenesis is the cause of both.
- Drones develop from unfertilized eggs (parthenogenesis), meaning they have no father. Because they are haploid, they cannot produce male offspring (sons) through fertilizationβthey only produce females (daughters) when their sperm fertilizes an egg. Thus, parthenogenesis is the foundational mechanism for both unique traits.
- Option A β Drones are haploid, not diploid.
- Option C β Females are diploid, not haploid.
- Option D β Mitosis is a consequence of their haploidy, not the cause of the parent-offspring restriction.
Used: : Elimination
Application: Identifying the root cause of haplodiploid inheritance patterns.
Final Logic: No fertilization $\rightarrow$ No father.
Un-Fathered = Un-Fertilized.
14 Q14. Arrange the honey bee individuals by their chromosome sets (n = 16):
1. Drone (n)
2. Queen (2n)
3. Worker (2n)
4. Sperm produced by Drone (n)
Drone = Haploid (n). Queen/Worker = Diploid (2n). Sperm from Drone = Haploid (mitosis).
- In honey bees, the drone is haploid (n=16) and the queen and workers are diploid (2n=32). Since the drone is already haploid, he produces sperm via mitosis, so the sperm is also haploid (n=16). Thus, individuals 1 and 4 are haploid, while 2 and 3 are diploid.
- Option B, C, D β Incorrect identification of ploidy levels based on honey bee biology.
Used: : Dimensional/Unit Analysis
Application: Applying the $n/2n$ counts to the specified individuals.
Final Logic: $N, 2N, 2N, N$ clearly separates the groups.
Queen/Worker = 2 (Diploid), Drone/Sperm = 1 (Haploid).
15 Q15. Evaluate the following statements regarding mutation mechanisms:
Statement I: Recombination and mutation both lead to variation in DNA.
Statement II: A single DNA helix runs continuously in each chromatid in a supercoiled form.
Mutation/Recombination = Genetic variation. Chromatid structure = Continuous supercoiled DNA.
- Statement I is a core principle: mutation and recombination are the two main drivers of genetic variation. Statement II is also technically correct: a chromatid is a highly condensed, supercoiled form of a single continuous DNA molecule. Both statements represent valid genetic concepts.
- Option B, C, D β Both statements are biologically verified concepts within the NCERT curriculum.
Used: : Contextual/Tonal Matching
Application: Evaluating two distinct genetic facts simultaneously.
Final Logic: Variation sources and structural packaging are both core concepts.
Variation = Mutation + Recombination.
16 Q16. How does the supercoiled form of the DNA helix relate to chromosomal alterations?
DNA is continuous in a chromatid. Breaking or altering this continuous structure (loss/gain) changes the whole chromosome. This is the basis of chromosomal aberrations.
- Because each chromatid contains a single, continuous, supercoiled DNA helix, any loss (deletion) or gain (insertion) of a segment physically breaks and rearranges this continuity. This structural change is what we define as a chromosomal aberration. This directly links the physical structure of DNA to the resulting genetic alteration.
- Option A β Supercoiling does not prevent mutation or loss.
- Option C β Supercoiling occurs in all gene-containing chromatids.
- Option D β Mutation can occur regardless of supercoiling state.
Used: : Contextual/Tonal Matching
Application: Relating DNA topology to genetic integrity.
Final Logic: Continuity means that damage is not local but affects the whole chromatid.
Continuous = One whole (any cut changes the whole).
17 Q17. The term "aberration" in chromosomal genetics refers to:
Aberration = Abnormal/Deviation. Chromosomal aberration = Structural change. Includes deletions, duplications, etc.
- In genetics, "aberration" specifically denotes a structural deviation from the normal chromosomal morphology. This deviation is typically caused by deletions, duplications, inversions, or translocations, which involve the loss or gain of DNA segments. Option B provides the accurate definition.
- Option A β Normal movement is "segregation," not aberration.
- Option C β Crossing over is a normal, healthy process.
- Option D β Stable transmission is the definition of "heredity," not aberration.
Used: : Elimination
Application: Defining "aberration" by excluding normal cellular processes.
Final Logic: Aberration = Structural Abnormality.
Aberration = Abnormal behavior.
18 Q18. Which of the following is NOT associated with chromosomal aberrations in the context of disease?
Mendelian disorders (like Hemophilia) are point mutations in single genes. Chromosomal aberrations are structural/numerical changes. They are distinct categories.
- Mendelian disorders (like Hemophilia or Sickle Cell Anemia) are caused by alterations or mutations in a single gene. Chromosomal aberrations are structural/numerical changes that affect large segments or entire chromosomes (e.g., Down syndrome, cancer). Thus, B is not a correct association.
- Option A β Correct; cancer is associated with chromosomal instability.
- Option C β Correct; this defines an aberration.
- Option D β Correct; changing chromosomes changes the genotype.
Used: : Substitution
Application: Categorizing disorders as either "Mendelian" (single-gene) or "Chromosomal" (structural).
Final Logic: Single gene $\neq$ Chromosomal aberration.
Mendelian = Single Gene; Chromosomal = Structural.
19
Passage mentions Henking's work on insects. This work served as the "initial clue." It helped establish chromosomal sex determination.
- The passage specifically identifies Henking's insect study as the "initial clue" for understanding sex determination. This research allowed later scientists to formulate the chromosomal basis for gender, moving the field forward.
- Option A β False; many organisms have them.
- Option C β False; insects undergo meiosis.
- Option D β False; insects (XO/XY) differ from birds (ZW).
Used: : Contextual/Tonal Matching
Application: Drawing directly from the text provided in the passage.
Final Logic: Text states: "initial clue... can be traced back to... experiments carried out in insects."
Initial Clue = Insects.
20
50% presence vs 50% absence in sperm. This variance provides the 1:1 ratio. Implies a genetic basis.
- The consistent 50% distribution of a physical nuclear structure (the X chromosome) provided the necessary evidence for later scientists to conclude that sex determination is a genetic, chromosomal process rather than an environmental or random phenomenon.
- Option A β The distribution pattern suggests internal genetics, not environment.
- Option C β The 50% split means they are not identical.
- Option D β While the father may determine sex in XY, the presence of the structure suggests a complex chromosomal mechanism for the whole species.
Used: : Elimination
Application: Determining what a 50/50 split in a cell structure suggests (two distinct populations).
Final Logic: Two distinct populations of sperm = A mechanism for two outcomes (sex).
Two types = Two sexes.
